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dundee open microscopy environment
Dundee Open Microscopy Environment, supplied by Glencoe Software Inc, used in various techniques. Bioz Stars score: 95/100, based on 1018 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dundee+open+microscopy+environment/OMERO/pmc12666330-11-5-7
Average 95 stars, based on 1018 article reviews
Dundee Open Microscopy Environment, supplied by Glencoe Software Inc, used in various techniques. Bioz Stars score: 95/100, based on 1018 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/dundee+open+microscopy+environment/OMERO/pmc12666330-11-5-7
Average 95 stars, based on 1018 article reviews
dundee open microscopy environment - by Bioz Stars,
2026-09
95/100 stars
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Quantitative RT-PCR:Article Title: Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER SYBR Green PCR Master Mix Applied Biosystems Cat#43-643-46 Protein G Sepharose beads 4 Fast Flow GE Healthcare Cat#GE17-0618-01 Clarity ECL Western Blotting Substrate Bio-Rad Cat#1705061 Clarity Max ECL Western Blotting Substrate Bio-Rad Cat#1705062 Giemsa stain Sigma Cat#GS500 MOWIOL 488 Calbiochem Cat#475904 ATM Inhibitor KU55933 Santa Cruz Cat#sc-202963 TBK1 Inhibitor MRT67307 MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee N/A PARP Inhibitor PJ34 Sigma Cat#P4365 Brefeldin A eBioscience Cat#00-4506-51 Ubc13 inhibitor NSC697923 Sigma Cat#SML0618 Critical Commercial Assays CellTox Green Cytotoxicity Assay Promega Cat#G8741 Annexin V apoptosis detection kit eBioscience Cat#88-8005 Cell Fractionation Kit Cell Signaling Cat#9038 Human IL-6 DuoSet ELISA R&D Systems Cat#DY206-05 One-Glo Luciferase Reporter Assay System Promega Cat#E6110 Lightcycler480 High Resolution Melting master mix Roche Cat#04909631001 EZNA total RNA Kit Omega Bio-TEK Cat#R6834-02 iScript cDNA Synthesis Kit Bio-Rad Cat#170-8891 RT2 First Strand Mix QIAGEN Cat#330401 RT2 Profiler PCR Array Human Cytokines and Chemokines QIAGEN Cat#PAHS-150ZF Deposited Data Raw data of images This paper, Mendeley Data https://doi.org/10.17632/5vxm8rptk2.1 Experimental Models: Cell Lines Human: cell line HaCaT DKFZ Cat#300493 Human: IFI16-deficient HaCaT cells BF4 Almine et al., 2017 N/A Human: IFI16-deficient HaCaT cells 4-11 Almine et al., 2017 N/A Human: STING-deficient HaCaT cells 3-B3 This Paper N/A Human: STING-deficient HaCaT cells 3-C8 This Paper N/A Human: cGAS-deficient HaCaT cells 1-A8 Almine et al., 2017 N/A Human: cGAS-deficient HaCaT cells 2-A6 This Paper N/A Human: TRAF6-deficient HaCaT cells 22 Strickson et al., 2017 N/A Human: TRAF6-deficient HaCaT cells 44 Strickson et al., 2017 N/A Human: HEK293 cells expressing pGreenFire-ISRE Dr. Jan Rehwinkel N/A Human: cell line NHEK Lonza Cat#192627 Human: cell line MRC-5 Dr. Michael Nevels N/A Human: cell line THP1 ECACC; Dr. Martin Jakobsen ECACC 88081201; Jønsson et al., 2017 Human: IFI16-deficient THP1 cells Jønsson et al., 2017 N/A Human: STING-deficient THP1 cells Jønsson et al., 2017 N/A Human: cGAS-deficient THP1 cells Jønsson et al., 2017 N/A Oligonucleotides Non-targeting siRNA pool GE Dharmacon Cat#D-001810-10-05 IFI16-targeting siRNA pool GE Dharmacon Cat#L-020004-00-0005 STING-targeting siRNA pool GE Dharmacon Cat#L-024333-02-0005 (Continued on next page) e2 Molecular Cell 71, 745–760.e1–e5, September 6, 2018 .. REAGENT or RESOURCE SOURCE IDENTIFIER cGAS-targeting siRNA pool GE Dharmacon Cat#L-015607-02-0005 p53-targeting siRNA pool GE Dharmacon Cat#L-003329-00-0005 See Table S1 for qRT-PCR primer sequences N/A N/A Recombinant DNA pcDNA3: p53 WT Loughery et al., 2014 Addgene 69003 pcDNA3: p53 S15A Loughery et al., 2014 Addgene 69004 pcDNA3: p53 S15D Loughery et al., 2014 Addgene 69005 pcDNA3.1: IFI16-Flag This Paper N/A pcDNA3.1: STING-Flag DR L. Jin, Albany Medical Centre N/A HA-Ubiquitin A. Mansell, Monash University N/A TRAF2 Tularik, San Francisco N/A TRAF3 Tularik Inc., San Francisco N/A TRAF6 Tularik Inc., San Francisco N/A Software and Algorithms Odyssey imaging system LI-COR Biosciences LI-COR Biosciences Image Lab Bio-Rad http://www.bio-rad.com/en-uk/product/ image-lab-software?ID=KRE6P5E8Z Zen Microscope software Zeiss https://www.zeiss.com/microscopy/int/ products/microscope-software/zen.html OMERO University of Recombinant:Article Title: Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER SYBR Green PCR Master Mix Applied Biosystems Cat#43-643-46 Protein G Sepharose beads 4 Fast Flow GE Healthcare Cat#GE17-0618-01 Clarity ECL Western Blotting Substrate Bio-Rad Cat#1705061 Clarity Max ECL Western Blotting Substrate Bio-Rad Cat#1705062 Giemsa stain Sigma Cat#GS500 MOWIOL 488 Calbiochem Cat#475904 ATM Inhibitor KU55933 Santa Cruz Cat#sc-202963 TBK1 Inhibitor MRT67307 MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee N/A PARP Inhibitor PJ34 Sigma Cat#P4365 Brefeldin A eBioscience Cat#00-4506-51 Ubc13 inhibitor NSC697923 Sigma Cat#SML0618 Critical Commercial Assays CellTox Green Cytotoxicity Assay Promega Cat#G8741 Annexin V apoptosis detection kit eBioscience Cat#88-8005 Cell Fractionation Kit Cell Signaling Cat#9038 Human IL-6 DuoSet ELISA R&D Systems Cat#DY206-05 One-Glo Luciferase Reporter Assay System Promega Cat#E6110 Lightcycler480 High Resolution Melting master mix Roche Cat#04909631001 EZNA total RNA Kit Omega Bio-TEK Cat#R6834-02 iScript cDNA Synthesis Kit Bio-Rad Cat#170-8891 RT2 First Strand Mix QIAGEN Cat#330401 RT2 Profiler PCR Array Human Cytokines and Chemokines QIAGEN Cat#PAHS-150ZF Deposited Data Raw data of images This paper, Mendeley Data https://doi.org/10.17632/5vxm8rptk2.1 Experimental Models: Cell Lines Human: cell line HaCaT DKFZ Cat#300493 Human: IFI16-deficient HaCaT cells BF4 Almine et al., 2017 N/A Human: IFI16-deficient HaCaT cells 4-11 Almine et al., 2017 N/A Human: STING-deficient HaCaT cells 3-B3 This Paper N/A Human: STING-deficient HaCaT cells 3-C8 This Paper N/A Human: cGAS-deficient HaCaT cells 1-A8 Almine et al., 2017 N/A Human: cGAS-deficient HaCaT cells 2-A6 This Paper N/A Human: TRAF6-deficient HaCaT cells 22 Strickson et al., 2017 N/A Human: TRAF6-deficient HaCaT cells 44 Strickson et al., 2017 N/A Human: HEK293 cells expressing pGreenFire-ISRE Dr. Jan Rehwinkel N/A Human: cell line NHEK Lonza Cat#192627 Human: cell line MRC-5 Dr. Michael Nevels N/A Human: cell line THP1 ECACC; Dr. Martin Jakobsen ECACC 88081201; Jønsson et al., 2017 Human: IFI16-deficient THP1 cells Jønsson et al., 2017 N/A Human: STING-deficient THP1 cells Jønsson et al., 2017 N/A Human: cGAS-deficient THP1 cells Jønsson et al., 2017 N/A Oligonucleotides Non-targeting siRNA pool GE Dharmacon Cat#D-001810-10-05 IFI16-targeting siRNA pool GE Dharmacon Cat#L-020004-00-0005 STING-targeting siRNA pool GE Dharmacon Cat#L-024333-02-0005 (Continued on next page) e2 Molecular Cell 71, 745–760.e1–e5, September 6, 2018 .. REAGENT or RESOURCE SOURCE IDENTIFIER cGAS-targeting siRNA pool GE Dharmacon Cat#L-015607-02-0005 p53-targeting siRNA pool GE Dharmacon Cat#L-003329-00-0005 See Table S1 for qRT-PCR primer sequences N/A N/A Recombinant DNA pcDNA3: p53 WT Loughery et al., 2014 Addgene 69003 pcDNA3: p53 S15A Loughery et al., 2014 Addgene 69004 pcDNA3: p53 S15D Loughery et al., 2014 Addgene 69005 pcDNA3.1: IFI16-Flag This Paper N/A pcDNA3.1: STING-Flag DR L. Jin, Albany Medical Centre N/A HA-Ubiquitin A. Mansell, Monash University N/A TRAF2 Tularik, San Francisco N/A TRAF3 Tularik Inc., San Francisco N/A TRAF6 Tularik Inc., San Francisco N/A Software and Algorithms Odyssey imaging system LI-COR Biosciences LI-COR Biosciences Image Lab Bio-Rad http://www.bio-rad.com/en-uk/product/ image-lab-software?ID=KRE6P5E8Z Zen Microscope software Zeiss https://www.zeiss.com/microscopy/int/ products/microscope-software/zen.html OMERO University of Article Title: Bridging mesoscopic and microscopic scales in multiple sclerosis: Post mortem brain block multi-contrast 9.4T MRI and histology quantification. Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, peptides and recombinant proteins Formaldehyde solution 4%, buffered, pH 6.9 Sigma-Aldrich 100496 PBS (phosphate-buffered saline) Sigma-Aldrich P4417 Biological samples Blocks from brains of adult multiple sclerosis patients German MS Brain Bank of the Competence Network Multiple Sclerosis (KKNMS), University of Gö ttingen NA Software and algorithms OMERO v.5.6.3 University of Software:Article Title: Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER SYBR Green PCR Master Mix Applied Biosystems Cat#43-643-46 Protein G Sepharose beads 4 Fast Flow GE Healthcare Cat#GE17-0618-01 Clarity ECL Western Blotting Substrate Bio-Rad Cat#1705061 Clarity Max ECL Western Blotting Substrate Bio-Rad Cat#1705062 Giemsa stain Sigma Cat#GS500 MOWIOL 488 Calbiochem Cat#475904 ATM Inhibitor KU55933 Santa Cruz Cat#sc-202963 TBK1 Inhibitor MRT67307 MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee N/A PARP Inhibitor PJ34 Sigma Cat#P4365 Brefeldin A eBioscience Cat#00-4506-51 Ubc13 inhibitor NSC697923 Sigma Cat#SML0618 Critical Commercial Assays CellTox Green Cytotoxicity Assay Promega Cat#G8741 Annexin V apoptosis detection kit eBioscience Cat#88-8005 Cell Fractionation Kit Cell Signaling Cat#9038 Human IL-6 DuoSet ELISA R&D Systems Cat#DY206-05 One-Glo Luciferase Reporter Assay System Promega Cat#E6110 Lightcycler480 High Resolution Melting master mix Roche Cat#04909631001 EZNA total RNA Kit Omega Bio-TEK Cat#R6834-02 iScript cDNA Synthesis Kit Bio-Rad Cat#170-8891 RT2 First Strand Mix QIAGEN Cat#330401 RT2 Profiler PCR Array Human Cytokines and Chemokines QIAGEN Cat#PAHS-150ZF Deposited Data Raw data of images This paper, Mendeley Data https://doi.org/10.17632/5vxm8rptk2.1 Experimental Models: Cell Lines Human: cell line HaCaT DKFZ Cat#300493 Human: IFI16-deficient HaCaT cells BF4 Almine et al., 2017 N/A Human: IFI16-deficient HaCaT cells 4-11 Almine et al., 2017 N/A Human: STING-deficient HaCaT cells 3-B3 This Paper N/A Human: STING-deficient HaCaT cells 3-C8 This Paper N/A Human: cGAS-deficient HaCaT cells 1-A8 Almine et al., 2017 N/A Human: cGAS-deficient HaCaT cells 2-A6 This Paper N/A Human: TRAF6-deficient HaCaT cells 22 Strickson et al., 2017 N/A Human: TRAF6-deficient HaCaT cells 44 Strickson et al., 2017 N/A Human: HEK293 cells expressing pGreenFire-ISRE Dr. Jan Rehwinkel N/A Human: cell line NHEK Lonza Cat#192627 Human: cell line MRC-5 Dr. Michael Nevels N/A Human: cell line THP1 ECACC; Dr. Martin Jakobsen ECACC 88081201; Jønsson et al., 2017 Human: IFI16-deficient THP1 cells Jønsson et al., 2017 N/A Human: STING-deficient THP1 cells Jønsson et al., 2017 N/A Human: cGAS-deficient THP1 cells Jønsson et al., 2017 N/A Oligonucleotides Non-targeting siRNA pool GE Dharmacon Cat#D-001810-10-05 IFI16-targeting siRNA pool GE Dharmacon Cat#L-020004-00-0005 STING-targeting siRNA pool GE Dharmacon Cat#L-024333-02-0005 (Continued on next page) e2 Molecular Cell 71, 745–760.e1–e5, September 6, 2018 .. REAGENT or RESOURCE SOURCE IDENTIFIER cGAS-targeting siRNA pool GE Dharmacon Cat#L-015607-02-0005 p53-targeting siRNA pool GE Dharmacon Cat#L-003329-00-0005 See Table S1 for qRT-PCR primer sequences N/A N/A Recombinant DNA pcDNA3: p53 WT Loughery et al., 2014 Addgene 69003 pcDNA3: p53 S15A Loughery et al., 2014 Addgene 69004 pcDNA3: p53 S15D Loughery et al., 2014 Addgene 69005 pcDNA3.1: IFI16-Flag This Paper N/A pcDNA3.1: STING-Flag DR L. Jin, Albany Medical Centre N/A HA-Ubiquitin A. Mansell, Monash University N/A TRAF2 Tularik, San Francisco N/A TRAF3 Tularik Inc., San Francisco N/A TRAF6 Tularik Inc., San Francisco N/A Software and Algorithms Odyssey imaging system LI-COR Biosciences LI-COR Biosciences Image Lab Bio-Rad http://www.bio-rad.com/en-uk/product/ image-lab-software?ID=KRE6P5E8Z Zen Microscope software Zeiss https://www.zeiss.com/microscopy/int/ products/microscope-software/zen.html OMERO University of Article Title: Bridging mesoscopic and microscopic scales in multiple sclerosis: Post mortem brain block multi-contrast 9.4T MRI and histology quantification. Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, peptides and recombinant proteins Formaldehyde solution 4%, buffered, pH 6.9 Sigma-Aldrich 100496 PBS (phosphate-buffered saline) Sigma-Aldrich P4417 Biological samples Blocks from brains of adult multiple sclerosis patients German MS Brain Bank of the Competence Network Multiple Sclerosis (KKNMS), University of Gö ttingen NA Software and algorithms OMERO v.5.6.3 University of Imaging:Article Title: Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER SYBR Green PCR Master Mix Applied Biosystems Cat#43-643-46 Protein G Sepharose beads 4 Fast Flow GE Healthcare Cat#GE17-0618-01 Clarity ECL Western Blotting Substrate Bio-Rad Cat#1705061 Clarity Max ECL Western Blotting Substrate Bio-Rad Cat#1705062 Giemsa stain Sigma Cat#GS500 MOWIOL 488 Calbiochem Cat#475904 ATM Inhibitor KU55933 Santa Cruz Cat#sc-202963 TBK1 Inhibitor MRT67307 MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee N/A PARP Inhibitor PJ34 Sigma Cat#P4365 Brefeldin A eBioscience Cat#00-4506-51 Ubc13 inhibitor NSC697923 Sigma Cat#SML0618 Critical Commercial Assays CellTox Green Cytotoxicity Assay Promega Cat#G8741 Annexin V apoptosis detection kit eBioscience Cat#88-8005 Cell Fractionation Kit Cell Signaling Cat#9038 Human IL-6 DuoSet ELISA R&D Systems Cat#DY206-05 One-Glo Luciferase Reporter Assay System Promega Cat#E6110 Lightcycler480 High Resolution Melting master mix Roche Cat#04909631001 EZNA total RNA Kit Omega Bio-TEK Cat#R6834-02 iScript cDNA Synthesis Kit Bio-Rad Cat#170-8891 RT2 First Strand Mix QIAGEN Cat#330401 RT2 Profiler PCR Array Human Cytokines and Chemokines QIAGEN Cat#PAHS-150ZF Deposited Data Raw data of images This paper, Mendeley Data https://doi.org/10.17632/5vxm8rptk2.1 Experimental Models: Cell Lines Human: cell line HaCaT DKFZ Cat#300493 Human: IFI16-deficient HaCaT cells BF4 Almine et al., 2017 N/A Human: IFI16-deficient HaCaT cells 4-11 Almine et al., 2017 N/A Human: STING-deficient HaCaT cells 3-B3 This Paper N/A Human: STING-deficient HaCaT cells 3-C8 This Paper N/A Human: cGAS-deficient HaCaT cells 1-A8 Almine et al., 2017 N/A Human: cGAS-deficient HaCaT cells 2-A6 This Paper N/A Human: TRAF6-deficient HaCaT cells 22 Strickson et al., 2017 N/A Human: TRAF6-deficient HaCaT cells 44 Strickson et al., 2017 N/A Human: HEK293 cells expressing pGreenFire-ISRE Dr. Jan Rehwinkel N/A Human: cell line NHEK Lonza Cat#192627 Human: cell line MRC-5 Dr. Michael Nevels N/A Human: cell line THP1 ECACC; Dr. Martin Jakobsen ECACC 88081201; Jønsson et al., 2017 Human: IFI16-deficient THP1 cells Jønsson et al., 2017 N/A Human: STING-deficient THP1 cells Jønsson et al., 2017 N/A Human: cGAS-deficient THP1 cells Jønsson et al., 2017 N/A Oligonucleotides Non-targeting siRNA pool GE Dharmacon Cat#D-001810-10-05 IFI16-targeting siRNA pool GE Dharmacon Cat#L-020004-00-0005 STING-targeting siRNA pool GE Dharmacon Cat#L-024333-02-0005 (Continued on next page) e2 Molecular Cell 71, 745–760.e1–e5, September 6, 2018 .. REAGENT or RESOURCE SOURCE IDENTIFIER cGAS-targeting siRNA pool GE Dharmacon Cat#L-015607-02-0005 p53-targeting siRNA pool GE Dharmacon Cat#L-003329-00-0005 See Table S1 for qRT-PCR primer sequences N/A N/A Recombinant DNA pcDNA3: p53 WT Loughery et al., 2014 Addgene 69003 pcDNA3: p53 S15A Loughery et al., 2014 Addgene 69004 pcDNA3: p53 S15D Loughery et al., 2014 Addgene 69005 pcDNA3.1: IFI16-Flag This Paper N/A pcDNA3.1: STING-Flag DR L. Jin, Albany Medical Centre N/A HA-Ubiquitin A. Mansell, Monash University N/A TRAF2 Tularik, San Francisco N/A TRAF3 Tularik Inc., San Francisco N/A TRAF6 Tularik Inc., San Francisco N/A Software and Algorithms Odyssey imaging system LI-COR Biosciences LI-COR Biosciences Image Lab Bio-Rad http://www.bio-rad.com/en-uk/product/ image-lab-software?ID=KRE6P5E8Z Zen Microscope software Zeiss https://www.zeiss.com/microscopy/int/ products/microscope-software/zen.html OMERO University of Microscopy:Article Title: Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER SYBR Green PCR Master Mix Applied Biosystems Cat#43-643-46 Protein G Sepharose beads 4 Fast Flow GE Healthcare Cat#GE17-0618-01 Clarity ECL Western Blotting Substrate Bio-Rad Cat#1705061 Clarity Max ECL Western Blotting Substrate Bio-Rad Cat#1705062 Giemsa stain Sigma Cat#GS500 MOWIOL 488 Calbiochem Cat#475904 ATM Inhibitor KU55933 Santa Cruz Cat#sc-202963 TBK1 Inhibitor MRT67307 MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee N/A PARP Inhibitor PJ34 Sigma Cat#P4365 Brefeldin A eBioscience Cat#00-4506-51 Ubc13 inhibitor NSC697923 Sigma Cat#SML0618 Critical Commercial Assays CellTox Green Cytotoxicity Assay Promega Cat#G8741 Annexin V apoptosis detection kit eBioscience Cat#88-8005 Cell Fractionation Kit Cell Signaling Cat#9038 Human IL-6 DuoSet ELISA R&D Systems Cat#DY206-05 One-Glo Luciferase Reporter Assay System Promega Cat#E6110 Lightcycler480 High Resolution Melting master mix Roche Cat#04909631001 EZNA total RNA Kit Omega Bio-TEK Cat#R6834-02 iScript cDNA Synthesis Kit Bio-Rad Cat#170-8891 RT2 First Strand Mix QIAGEN Cat#330401 RT2 Profiler PCR Array Human Cytokines and Chemokines QIAGEN Cat#PAHS-150ZF Deposited Data Raw data of images This paper, Mendeley Data https://doi.org/10.17632/5vxm8rptk2.1 Experimental Models: Cell Lines Human: cell line HaCaT DKFZ Cat#300493 Human: IFI16-deficient HaCaT cells BF4 Almine et al., 2017 N/A Human: IFI16-deficient HaCaT cells 4-11 Almine et al., 2017 N/A Human: STING-deficient HaCaT cells 3-B3 This Paper N/A Human: STING-deficient HaCaT cells 3-C8 This Paper N/A Human: cGAS-deficient HaCaT cells 1-A8 Almine et al., 2017 N/A Human: cGAS-deficient HaCaT cells 2-A6 This Paper N/A Human: TRAF6-deficient HaCaT cells 22 Strickson et al., 2017 N/A Human: TRAF6-deficient HaCaT cells 44 Strickson et al., 2017 N/A Human: HEK293 cells expressing pGreenFire-ISRE Dr. Jan Rehwinkel N/A Human: cell line NHEK Lonza Cat#192627 Human: cell line MRC-5 Dr. Michael Nevels N/A Human: cell line THP1 ECACC; Dr. Martin Jakobsen ECACC 88081201; Jønsson et al., 2017 Human: IFI16-deficient THP1 cells Jønsson et al., 2017 N/A Human: STING-deficient THP1 cells Jønsson et al., 2017 N/A Human: cGAS-deficient THP1 cells Jønsson et al., 2017 N/A Oligonucleotides Non-targeting siRNA pool GE Dharmacon Cat#D-001810-10-05 IFI16-targeting siRNA pool GE Dharmacon Cat#L-020004-00-0005 STING-targeting siRNA pool GE Dharmacon Cat#L-024333-02-0005 (Continued on next page) e2 Molecular Cell 71, 745–760.e1–e5, September 6, 2018 .. REAGENT or RESOURCE SOURCE IDENTIFIER cGAS-targeting siRNA pool GE Dharmacon Cat#L-015607-02-0005 p53-targeting siRNA pool GE Dharmacon Cat#L-003329-00-0005 See Table S1 for qRT-PCR primer sequences N/A N/A Recombinant DNA pcDNA3: p53 WT Loughery et al., 2014 Addgene 69003 pcDNA3: p53 S15A Loughery et al., 2014 Addgene 69004 pcDNA3: p53 S15D Loughery et al., 2014 Addgene 69005 pcDNA3.1: IFI16-Flag This Paper N/A pcDNA3.1: STING-Flag DR L. Jin, Albany Medical Centre N/A HA-Ubiquitin A. Mansell, Monash University N/A TRAF2 Tularik, San Francisco N/A TRAF3 Tularik Inc., San Francisco N/A TRAF6 Tularik Inc., San Francisco N/A Software and Algorithms Odyssey imaging system LI-COR Biosciences LI-COR Biosciences Image Lab Bio-Rad http://www.bio-rad.com/en-uk/product/ image-lab-software?ID=KRE6P5E8Z Zen Microscope software Zeiss https://www.zeiss.com/microscopy/int/ products/microscope-software/zen.html OMERO University of Polymerase Chain Reaction:Article Title: Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER SYBR Green PCR Master Mix Applied Biosystems Cat#43-643-46 Protein G Sepharose beads 4 Fast Flow GE Healthcare Cat#GE17-0618-01 Clarity ECL Western Blotting Substrate Bio-Rad Cat#1705061 Clarity Max ECL Western Blotting Substrate Bio-Rad Cat#1705062 Giemsa stain Sigma Cat#GS500 MOWIOL 488 Calbiochem Cat#475904 ATM Inhibitor KU55933 Santa Cruz Cat#sc-202963 TBK1 Inhibitor MRT67307 MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee N/A PARP Inhibitor PJ34 Sigma Cat#P4365 Brefeldin A eBioscience Cat#00-4506-51 Ubc13 inhibitor NSC697923 Sigma Cat#SML0618 Critical Commercial Assays CellTox Green Cytotoxicity Assay Promega Cat#G8741 Annexin V apoptosis detection kit eBioscience Cat#88-8005 Cell Fractionation Kit Cell Signaling Cat#9038 Human IL-6 DuoSet ELISA R&D Systems Cat#DY206-05 One-Glo Luciferase Reporter Assay System Promega Cat#E6110 Lightcycler480 High Resolution Melting master mix Roche Cat#04909631001 EZNA total RNA Kit Omega Bio-TEK Cat#R6834-02 iScript cDNA Synthesis Kit Bio-Rad Cat#170-8891 RT2 First Strand Mix QIAGEN Cat#330401 RT2 Profiler PCR Array Human Cytokines and Chemokines QIAGEN Cat#PAHS-150ZF Deposited Data Raw data of images This paper, Mendeley Data https://doi.org/10.17632/5vxm8rptk2.1 Experimental Models: Cell Lines Human: cell line HaCaT DKFZ Cat#300493 Human: IFI16-deficient HaCaT cells BF4 Almine et al., 2017 N/A Human: IFI16-deficient HaCaT cells 4-11 Almine et al., 2017 N/A Human: STING-deficient HaCaT cells 3-B3 This Paper N/A Human: STING-deficient HaCaT cells 3-C8 This Paper N/A Human: cGAS-deficient HaCaT cells 1-A8 Almine et al., 2017 N/A Human: cGAS-deficient HaCaT cells 2-A6 This Paper N/A Human: TRAF6-deficient HaCaT cells 22 Strickson et al., 2017 N/A Human: TRAF6-deficient HaCaT cells 44 Strickson et al., 2017 N/A Human: HEK293 cells expressing pGreenFire-ISRE Dr. Jan Rehwinkel N/A Human: cell line NHEK Lonza Cat#192627 Human: cell line MRC-5 Dr. Michael Nevels N/A Human: cell line THP1 ECACC; Dr. Martin Jakobsen ECACC 88081201; Jønsson et al., 2017 Human: IFI16-deficient THP1 cells Jønsson et al., 2017 N/A Human: STING-deficient THP1 cells Jønsson et al., 2017 N/A Human: cGAS-deficient THP1 cells Jønsson et al., 2017 N/A Oligonucleotides Non-targeting siRNA pool GE Dharmacon Cat#D-001810-10-05 IFI16-targeting siRNA pool GE Dharmacon Cat#L-020004-00-0005 STING-targeting siRNA pool GE Dharmacon Cat#L-024333-02-0005 (Continued on next page) e2 Molecular Cell 71, 745–760.e1–e5, September 6, 2018 .. REAGENT or RESOURCE SOURCE IDENTIFIER cGAS-targeting siRNA pool GE Dharmacon Cat#L-015607-02-0005 p53-targeting siRNA pool GE Dharmacon Cat#L-003329-00-0005 See Table S1 for qRT-PCR primer sequences N/A N/A Recombinant DNA pcDNA3: p53 WT Loughery et al., 2014 Addgene 69003 pcDNA3: p53 S15A Loughery et al., 2014 Addgene 69004 pcDNA3: p53 S15D Loughery et al., 2014 Addgene 69005 pcDNA3.1: IFI16-Flag This Paper N/A pcDNA3.1: STING-Flag DR L. Jin, Albany Medical Centre N/A HA-Ubiquitin A. Mansell, Monash University N/A TRAF2 Tularik, San Francisco N/A TRAF3 Tularik Inc., San Francisco N/A TRAF6 Tularik Inc., San Francisco N/A Software and Algorithms Odyssey imaging system LI-COR Biosciences LI-COR Biosciences Image Lab Bio-Rad http://www.bio-rad.com/en-uk/product/ image-lab-software?ID=KRE6P5E8Z Zen Microscope software Zeiss https://www.zeiss.com/microscopy/int/ products/microscope-software/zen.html OMERO University of Saline:Article Title: Bridging mesoscopic and microscopic scales in multiple sclerosis: Post mortem brain block multi-contrast 9.4T MRI and histology quantification. Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Chemicals, peptides and recombinant proteins Formaldehyde solution 4%, buffered, pH 6.9 Sigma-Aldrich 100496 PBS (phosphate-buffered saline) Sigma-Aldrich P4417 Biological samples Blocks from brains of adult multiple sclerosis patients German MS Brain Bank of the Competence Network Multiple Sclerosis (KKNMS), University of Gö ttingen NA Software and algorithms OMERO v.5.6.3 University of |